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Antioxidant Activity of a Dihydroquercetin Isolated from Larix gmelinii (Rupr.) Rupr. Wood
Author(s) -
Kolhir V. K.,
Bykov V. A.,
Baginskaja A. I.,
Sokolov S. Y.,
Glazova N. G.,
Leskova T. E.,
Sakovich G. S.,
Tjukavki. A.,
Kolesnik Yu. A.,
Rulenko I. A.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199609)10:6<478::aid-ptr883>3.0.co;2-s
Subject(s) - antioxidant , quercetin , chemistry , lipid peroxidation , traditional medicine , pharmacognosy , pharmacology , flavonoid , biological activity , food science , biochemistry , biology , medicine , in vitro
We have demonstrated that dihydroquercetin is an antioxidant and possesses the properties of protecting capillaries, which is consistent with its action as an antiinflammatory agent, gastro‐ and hepatoprotecting agent, and its diuretic and hypolipidaemic activity. As a capillary protector, dihydroquercetin is 3.4 times more effective at a dose of 100 mg/kg and 4.9 times at a dose of 300 mg/kg than the well known bioflavonoid, quercetin. Dihydroquercetin shows a dose dependent suppression of lipid peroxidation in the rat liver. The hypolipidaemic activity of dihydroquercetin at 250 mg/kg is comparable to that of polysponin.