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Anticonvulsant Action of Withania somnifera (Aswaganda) Root Extract against Pentylenetetrazol‐induced Kindling in Mice
Author(s) -
Kulkarni S. K.,
George B.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199608)10:5<447::aid-ptr869>3.0.co;2-m
Subject(s) - pentylenetetrazol , kindling , convulsant , pharmacology , diazepam , anticonvulsant , withania somnifera , chemistry , medicine , traditional medicine , epilepsy , stimulation , endocrinology , receptor , biochemistry , psychiatry , alternative medicine , pathology
Repeated administration of pentylenetetrazol (PTZ, 30 mg/kg, thrice a week for 9 weeks) produced chemical kindling when mice were challenged with a subconvulsive dose of the convulsant. These animals were also found to be susceptible to seizures after a subconvulsant dose of a beta‐carboline, (FG 7142, 20 mg/kg). Withania somnifera root extract (100 mg/kg) offered a significant protection against PTZ‐induced chemical kindling, and the effect was comparable to diazepam (1 mg/kg). The protective effect of W. womnifera appears to involve GABAergic mediation.