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Effect of D‐400, an Ayurvedic Herbal Formulation on Experimentally Induced Diabetes Mellitus
Author(s) -
Mitra S. K.,
Gopumadhavan S.,
Muralidhar T. S.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199608)10:5<433::aid-ptr864>3.0.co;2-d
Subject(s) - diabetes mellitus , medicine , endocrinology , glycogenolysis , pancreas , streptozotocin , blood sugar , insulin , glucose homeostasis , endocrine system , glycogen , islet , homeostasis , alloxan , glucose tolerance test , insulin resistance , hormone
In the present study, after D‐400 treatment a significant reduction in blood sugar levels in alloxan induced diabetes was observed, an oral glucose tolerance test (OGTT) showed a significant lowering of AUC in streptozotocin induced diabetes in rats. There was a rise in hepatic glycogen level closer to normal after D‐400 treatment. In the pancreas of diabetic rats, D‐400 therapy showed a significant increase in islet number and beta cell count and appeared to bring about blood glucose homeostasis by increasing insulin secretion through repair/regeneration of endocrine pancreas which may be responsible for the prevention of hepatic glycogenolysis.