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Cytotoxic Activities of Colombian Plant Extracts on Chinese Hamster Lung Fibroblasts
Author(s) -
de Cerain Adela López,
Pinzón Roberto,
Calle Jairo,
Marín Ana,
Monge Antonio
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199608)10:5<431::aid-ptr863>3.0.co;2-m
Subject(s) - pharmacognosy , traditional medicine , chinese hamster , cytotoxic t cell , hamster , fibroblast , biology , medicine , biological activity , in vitro , microbiology and biotechnology , genetics
Fifty‐one crude extracts from 31 Colombian plants used in traditional medicine have been screened for cytotoxicity in a MTT assay with V79 cells. Eleven extracts (21%) were active, showing a survival percentage below 20% with respect to the controls. The most active were ethanol and dichloromethane extracts from Acnistus arborescens leaves. The IC 50 values obtained (6 and 11 μg/mL) encourage a more in depth investigation.