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Antiviral and Immunological Activity of a New Pavine Alkaloid (‐)‐Thalimonine Isolated from Thalictrum simplex
Author(s) -
Varadinova T. L.,
Shishkov S. A.,
Ivanovska N. D.,
Velcheva M. P.,
Danghaaghin Selenghe,
Samadanghiin Zhavzhan,
Yansanghiin Zhamyansan
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199608)10:5<414::aid-ptr876>3.0.co;2-5
Subject(s) - alkaloid , herpes simplex virus , in vitro , biology , virus , cell culture , virology , cell growth , microbiology and biotechnology , chemistry , biochemistry , stereochemistry , genetics
A pavine alkaloid (‐)‐thalimonine, at a nontoxic concentration range between 0.1 and 100 μ M was investigated for antiviral and immunological activity. The alkaloid irreversibly inhibited the replication of herpes simplex virus type 1 (HSV‐1) in MDBK cells with no effect on free virions. The (‐)‐thalimonine enhanced the proliferation induced by T‐cell mitogens (PHA, ConA) at lower concentrations and suppressed the action of B‐cell mitogen (LPS) in vitro . Splenic cells from mice pretreated with (‐)‐thalimonine had an elevated response to PHA and a lowered response to LPS.