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Antiherpetic Activity of S1, an Algal Derived Sulphated Galactan
Author(s) -
Pujol Carlos A.,
Errea Maria I.,
Matulewicz Maria C.,
Damonte Elsa B.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199608)10:5<410::aid-ptr875>3.0.co;2-k
Subject(s) - herpes simplex virus , cytotoxicity , virus , herpesviridae , mode of action , ic50 , mechanism of action , galactan , biology , virus quantification , cytolysis , chemistry , microbiology and biotechnology , virology , biochemistry , in vitro , polysaccharide , viral disease
The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV‐1 and HSV‐2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 γ g/mL that were in excess of the IC 50 values (range from 3.2 to 12.0 γg/mL for the different herpesviruses assayed). The antiherpetic action of S1 was independent of the host cell and the antiviral assay. The kinetics of infectious virus adsorption to the host cell was highly inhibited in the presence of S1 whereas the subsequent stage of virus penetration was not affected. The binding of radiolabelled HSV‐1 particles was inhibited in a dose dependent manner confirming that the mode of action of S1 could be attributable to an inhibition of initial virus attachment to the host cell.