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Effect of Silymarinphospholipid Complex on the Liver in Rabbits Maintained on a High‐fat Diet
Author(s) -
Droździk M.,
Juźwiak S.,
MachoyMokrzyńska A.,
Wójcicki J.,
Kałdońska M.,
Myśliwiec Z.,
Juzyszyn Z.,
Skowron J.,
Rózewicka L.,
Mścisz A.,
Gorecki P.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199608)10:5<406::aid-ptr871>3.0.co;2-f
Subject(s) - antioxidant , lecithin , medicine , endocrinology , cholesterol , coconut oil , microsome , biology , chemistry , food science , enzyme , biochemistry
Fifty mongrel rabbits were divided into five equal groups: (1) controls, (2) animals receiving a high‐fat diet (HFD), containing cholesteral and coconut oil, (3) HFD + silymarin, (4) HFD + lecithin (L), and (5) HFD + silymarinphospholipid complex (SPC). The experiment lasted 12 weeks. Histopathological alterations due to exposure to HFD were the least advanced in a group of animals maintained on HFD + SPC, compared with group 3 and group 4, and were near normal. A beneficial effect of SPC is most probably due to combined antioxidant (reduction of MDA concentration) and metabolic (fall in cholesterol content in liver homogenate and liver microsomes) properties. These findings suggest that SPC may be an effective agent in the protection against liver damage induced by a high‐fat diet.