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Analgesic Effects Induced by Hypoxoside, a Norlignan Glucoside from Hypoxis spp.
Author(s) -
Nicoletti Marcello,
Pieretti Stefano,
Capasso Anna,
Galeffi Corrado
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199608)10:5<398::aid-ptr860>3.0.co;2-7
Subject(s) - analgesic , rhizome , tail flick test , pharmacology , pharmacognosy , glucoside , medicine , traditional medicine , phytotherapy , anesthesia , nociception , chemistry , biological activity , in vitro , receptor , biochemistry , alternative medicine , pathology
Hypoxoside, a glucoside isolated from the rhizomes of Hypoxis spp., was investigated for its analgesic activity. Hypoxoside administered intraperitoneally at doses of 1, 5, 10 and 20 mg/kg did not induce gross behavioural alterations or locomotor impairment. Hypoxoside was able to reduce the response to chemical pain stimuli, such as in the formalin and in the writhing test, whereas it did not change the pain response in the hot plate or in the tail flick test. These results indicate that hypoxoside exerts analgesic effects probably via an antiinflammatory mechanism.