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Inhibitory Effect of Methanol Extracts from Edible Mushroom on TPA‐induced Ear Oedema and Tumour Promotion in Mouse Skin
Author(s) -
Yasukawa Ken,
Kanno Hiroshi,
Kaminaga Tomohiro,
Takido Michio,
Kasahara Yoshimasa,
Kumaki Kunio
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199606)10:4<367::aid-ptr852>3.0.co;2-d
Subject(s) - mushroom , tumor promotion , methanol , chemistry , dmba , traditional medicine , edible mushroom , pharmacology , biochemistry , food science , biology , carcinogenesis , medicine , organic chemistry , gene
Edible mushroom extracts inhibited 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐induced ear oedema in mice. Twenty seven methanol extracts obtained from mushrooms were assayed and their inhibition ratios calculated. The methanol extracts of Russula delica, Mycoleptodonoides aitchisonii, Lactarius deliciosus, Naematoloma sublateritium, Lyophyllum decastes and Lyophyllum connatum markedly inhibited the inflammatory activity induced by TPA in mice. The methanol extract from Mycoleptodonoides aitchisoni was found to inhibit tumour promotion in two‐stage carcinogenesis in mouse skin.