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Antimalarial Activity of Cryptolepine and Some Other Anhydronium Bases
Author(s) -
Wright C. W.,
Phillipson J. D.,
Awe S. O.,
Kirby G. C.,
Warhurst D. C.,
QuetinLeclercq J.,
Angenot L.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199606)10:4<361::aid-ptr845>3.0.co;2-n
Subject(s) - plasmodium berghei , plasmodium falciparum , chloroquine , pharmacognosy , malaria , pharmacology , in vitro , traditional medicine , biology , amodiaquine , chemistry , biological activity , medicine , immunology , biochemistry
Eight naturally occurring anhydronium bases and the synthetic quaternary compound N b ‐methylharmalane were tested against Plasmodium falciparum (strain K1) in vitro . Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6‐dihydroflavopereirine, matadine, N b ‐methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitaemia was suppressed by 80% at 50 mg/kg/day.