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Analgesic Activity and Effects on Isolated Smooth Muscle of Different Fractions of Hexane Extract from Araujia sericifera Brot
Author(s) -
Bello R.,
Barrachina M. D.,
Esplugues J.,
López de MedranoVillar M. J.,
PrimoYúfera E.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199606)10:4<337::aid-ptr829>3.0.co;2-z
Subject(s) - histamine , analgesic , methanol , chemistry , guinea pig , in vitro , biological activity , pharmacology , ileum , motility , biology , biochemistry , organic chemistry , endocrinology , genetics
The present study analyses the analgesic activity and action on in vitro motility of methanol soluble and methanol insoluble fractions obtained from the hexane extract of fruits from Araujia sericifera . The methanol fraction did not show any pharmacological activity on the different tests evaluated. However, the insoluble methanol fraction exhibited an interesting analgesic effect in models of chemical and thermal stimulus and it reduced the E max induced by histamine in vitro on guinea‐pig ileum. This extract lacked any central depressor activity since it did not modify the number of mouse movements in the activity cage.