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Antimalarial Activity of Cryptolepine and Isocryptolepine, Alkaloids Isolated from Cryptolepis sanguinolenta
Author(s) -
Grellier Phillippe,
Ramiaramanana Lobo,
Millerioux Valérie,
Deharo Eric,
Schrével Joseph,
Frappier François,
Trigalo François,
Bodo Bernard,
Pousset JeanLouis
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199606)10:4<317::aid-ptr858>3.0.co;2-0
Subject(s) - pharmacognosy , traditional medicine , alkaloid , biology , folk medicine , medicine , biological activity , botany , in vitro , genetics
Cryptolepis sanguinolenta extracts are currently used by African herbalists to cure malaria but the compounds involved in its antimalarial activity have not been identified. Two alkaloids, cryptolepine and isocryptolepine, have been isolated from the roots of C. sanguinolenta and their antimalarial activity evaluated. Both alkaloids possess intrinsic inhibitory activity against the human malaria parasite, Plasmodium falciparum in vitro , whatever the chloroquine‐resistance status of the strains used. Cryptolepine was slightly more efficient for parasite killing with an IC 50 in the range of 0.2 to 0.6 μ MSC compared with an IC 50 of about 0.8 μ MSC for isocryptolepine. The antimalarial activity of cryptolepine was confirmed in vivo on the rodent malarial parasites Plasmodium vinckei petteri and Plasmodium berghei ANKA.