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Antiinflammatory Effects of an Ethyl Acetate Extract of Euphorbia royleana
Author(s) -
Bani S.,
Chand D.,
Suri K. A.,
Suri O. P.,
Sharma O. P.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199606)10:4<285::aid-ptr761>3.0.co;2-p
Subject(s) - croton oil , croton , uterus , traditional medicine , chemistry , pharmacology , ethyl acetate , arthritis , pharmacognosy , vascular permeability , phytotherapy , medicine , biological activity , biochemistry , endocrinology , inflammation , in vitro , alternative medicine , pathology
The antiinflammatory activity of the ethyl acetate extract (EA) from the residue of an 85% alcohol extract of the latex of plant Euphorbia royleana was tested in mice and rats. In acute tests EA displayed marked antiinflammatory activity. Significant antiarthritic activity was observed in subacute and chronic models of formaldehyde‐induced arthritis, adjuvant‐induced developing and established arthritis. It produced inhibition of the exudate volume and the leucocyte migration in rats and vascular permeability in mice. EA showed a poor inhibitory effect on the granuloma formation by cotton pellet and croton oil. In in vitro studies EA inhibited the spontaneous contractions of the isolated pregnant rat uterus and oxytocin‐induced contractions of virgin rat uterus. It had a very low ulcerogenic potential. The oral LD 50 in both rats and mice was more than 2500 mg/kg.