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Solution and Colour Stability of the Bark Extract of Bridelia ferruginea Benth
Author(s) -
Orafidiya Lara O.,
Lamikanra A.,
Akueme Ifeoma D.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199605)10:3<266::aid-ptr815>3.0.co;2-i
Subject(s) - citric acid , bark (sound) , chemistry , ascorbic acid , tartaric acid , bottle , polyvinyl alcohol , ethanol , solvent , pharmacognosy , chromatography , food science , materials science , organic chemistry , biochemistry , biology , biological activity , ecology , composite material , in vitro
A solvent system consisting of water: propylene glycol: ethanol (2:2:1) was found suitable for diluting the ethanol bark extract and for reconstituting the freeze‐dried extract of Bridelia ferruginea Benth for preparation of a gargle formulation. Such solutions remained clear when subjected to high storage temperatures and eight freeze‐thaw cycles. The wine colour of Bridelia bark extract solution darkened on storage. Darkening was accelerated by heat while light had minimal effect. Inclusion of certain antioxidants—sodium metabisulphite, ascorbic acid and citric acid, reduced the colour change. Heating the freeze‐dried extract at 115°C for 4 h and at 130°C for at least 1 h arrested the colour change. When lime juice was added to the solution of the heated powder, the colour of the resulting solution became unstable implicating a pH effect on colour stability. The colour of bottle and use of carton for storage had no appreciable effect on colour stability.