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Xanthine Oxidase Inhibitory Activity of Flavonoids and Tannins from Hexachlamys edulis (Myrtaceae)
Author(s) -
SchmedaHirschmann G.,
Zúñiga J.,
DutraBehrens M.,
Habermehl G.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199605)10:3<260::aid-ptr811>3.0.co;2-b
Subject(s) - xanthine oxidase , gallic acid , chemistry , quercetin , myricetin , myrtaceae , rutin , pharmacognosy , stereochemistry , biochemistry , enzyme , biological activity , botany , biology , antioxidant , in vitro , kaempferol
The acetone‐water extract of Hexachlamys edulis (Myrtaceae) inhibited the enzyme xanthine oxidase (XO) in vitro . Bioassay‐guided isolation led to the gallic acid ester in 2″ of myricitrin (desmanthin‐1), (‐)‐epigallocatechin‐3‐O‐gallate (EGG) and pentagalloylglucose as the main XO inhibitors of H. edulis . Desmanthin‐1 and EGG were mixed‐type inhibitors of XO with K i values of 1.6×10 −4 M and 1.8×10 −4 M , respectively. Pentagalloylglucose was an uncompetitive XO inhibitor with a K ESI of 6.7×10 −6 M . From the active n ‐butanol soluble part of the aqueous acetone extract of H. edulis , several flavonoids were isolated. The flavonoids were mainly myricetin‐3‐O‐monoglycosides with the quercetin glycoside avicularin as a minor compound displaying a weak inhibitory activity towards XO.