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Screening of Traditional Medicines for their Inhibitory Activity Against HIV‐1 Protease
Author(s) -
Xu HongXi,
Wan Min,
Loh BoonNee,
Kon OiLian,
Chow PengWai,
Sim KengYeow
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199605)10:3<207::aid-ptr812>3.0.co;2-u
Subject(s) - terminalia chebula , traditional medicine , protease , paeonia suffruticosa , pharmacognosy , hiv 1 protease , chemistry , inhibitory postsynaptic potential , medicinal plants , biology , pharmacology , medicine , biological activity , biochemistry , enzyme , in vitro , neuroscience
Aqueous extracts of 75 different traditional medicines, currently used for the treatment of various human diseases in China, Japan and Indonesia, were screened for possible inhibitory activity against HIV‐1 protease using fluorogenic assay. Forty extracts exhibited inhibitory activity at a concentration of 250 μg/mL, and 18 of them inhibited HIV‐1 protease activity by more than 70%. Among the extracts examined, Belamcanda chinensis, Magnolia fargesii, Paeonia suffruticosa, Phellodendron amurense and Terminalia chebula were also effective at a concentration of 25 μg/mL in the fluorogenic assay.