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Post‐coital Contraceptive Action of Pueraria tuberosa DC. Extract in Rats
Author(s) -
Shukla Saangeeta
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199603)10:2<95::aid-ptr699>3.0.co;2-5
Subject(s) - ovary , endocrinology , glycogen , alkaline phosphatase , uterus , medicine , acid phosphatase , biology , muscle hypertrophy , estrous cycle , pharmacognosy , chemistry , traditional medicine , biological activity , enzyme , biochemistry , in vitro
Biochemical and physiological alterations have been observed in the ovary and uterus of pregnant rats treated with an extract of Pueraria tuberosa DC. Its administration from day 1 to 5 post‐coitally caused a significant increase in the wet weight, protein and glycogen contents. Activity of acid phosphatase and ATPase was depleted sharply on days 4 and 5, but the activity of alkaline phosphatase was elevated on days 4 and 5. Ovaries of treated rats showed an increased number of follicles of different age. Cells of the corpora lutea showed hypertrophy. Uterine histoarchitecture appeared nonreceptive on the day of implantation. No deciduoma was observed on day 5. These changes have been correlated with the antiimplantation action of the butanol extract.