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Action of Pluchea indica methanol extract as a dual inhibitor on PAF‐induced paw oedema and gastric damage
Author(s) -
Sen T.,
Ghosh T. K.,
Bhattacharjee S.,
Nag Chaudhuri A. K.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199602)10:1<74::aid-ptr763>3.0.co;2-w
Subject(s) - platelet activating factor , inflammation , medicine , pharmacology , tumor necrosis factor alpha , necrosis , traditional medicine , gastroenterology
The effect of the methanol fraction of Pluchea indica ( P. indica ) and certain standard drugs were evaluated on platelet activation factor (PAF)‐induced inflammation, gastric necrosis, ulceration and haematological picture. Administration of PAF (i.v.) for 20 min produced significant alteration in haematological profiles, considerable inflammation, severe gastric mucosal vasocongestion, necrosis and ulceration. Pretreatment with either P. indica and certain standard drugs significantly inhibited inflammation and incidences of lowered gastric damage.