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In vitro activities of Cedrela tubiflora aqueous leaf extracts on murine macrophages, polymorphonuclear leukocytes and complement
Author(s) -
Benencia F.,
Courrèges M. C.,
Coulombié F. C.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199602)10:1<37::aid-ptr770>3.0.co;2-z
Subject(s) - in vitro , respiratory burst , phagocytosis , immune system , complement system , biology , microbiology and biotechnology , chemistry , biochemistry , immunology
Cedrela tubiflora aqueous leaf extracts are capable of inhibiting in vitro the activity of some components of the mouse immune system related to inflammatory responses. A significant reduction in the phagocytic capability and respiratory burst response (61.5% and 57.6%, respectively) of murine peritoneal macrophages was observed when these cells were incubated for 24 h with medium containing 1 mg/mL extract. On the other hand, at a concentration of 4 mg/mL, the extract reduced significantly the phagocytic activity of mouse polymorphonuclear leukocytes (87.5%) without altering the oxidative metabolism of these cells. Finally, a concentration of 2 mg/mL was required to inhibit the haemolytic activity of both pathways of mouse complement.