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Pharmacological and toxicological investigations on Foeniculum vulgare dried fruit extract in experimental animals
Author(s) -
Tanira M. O. M.,
Shah A. H.,
Mohsin A.,
Ageel A. M.,
Qureshi S.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199602)10:1<33::aid-ptr769>3.0.co;2-l
Subject(s) - foeniculum , antipyretic , antimicrobial , analgesic , acute toxicity , diuretic , traditional medicine , pharmacology , toxicity , staphylococcus aureus , bacillus subtilis , pharmacognosy , chemistry , medicine , biological activity , biology , microbiology and biotechnology , bacteria , biochemistry , in vitro , genetics
The ethanol extract of the dried ripe fruit of Foeniculum vulgare (500 mg/kg) was tested for diuretic, analgesic, antipyretic, antimicrobial, cytotoxic activities and its effect on bile secretion in rats. Also, the acute toxicity after 0.5, 1 and 3 g/kg was investigated in mice. The extract showed diuretic, analgesic, antipyretic activities and it enhanced bile secretion. As an antimicrobial agent, the extract inhibited the growth of Staphylococcus aureus and Bacillus subtilis and showed a marked mitodepressive effect. At a dose of 3 g/kg, it caused piloerection and it depressed locomotor activity but caused no deaths when administered acutely to mice.