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Evaluation of the liver protective principles from the root of Cudrania cochinchinensis var. gerontogea
Author(s) -
Lin ChunChing,
Lee HsiangYu,
Chang ChengHsiung,
Namba Tsuneo,
Hattori Masao
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199602)10:1<13::aid-ptr764>3.0.co;2-1
Subject(s) - traditional medicine , pharmacognosy , medicine , biology , biological activity , biochemistry , in vitro
Three components in the EtOAc and n ‐BuOH fractions, obtained from the ethanol extract of Cudrania cochinchinensis var. gerontogea (Moraceae) were evaluated for their hepatoprotective activities in rats on carbon tetrachloride (CCl 4 ) and D ‐galactosamine ( D ‐GalN)‐induced hepatotoxicity. Three flavonoids (25 mg/kg), wighteone, naringenin and populnin (kaempferol‐7‐glucoside), exhibited greater hepatoprotective effects on CCl 4 ‐induced liver injury than on D ‐GalN‐induced hepatotoxicity by reversing the altered serum enzymes (SGOT and SGPT) and preventing the development of hepatic lesions, including liver centrilobular inflammation, cell necrosis, fatty change, ballooning degeneration in CCl 4 intoxication and necrosis of the portal area in D‐GalN intoxication. Wighteone and naringenin (25 mg/kg) isolated from the EtOAc fraction showed a better hepatoprotective effect against CCl 4 ‐induced liver injury than that of populnin (25 mg/kg) obtained from the n ‐BuOH fraction. Furthermore, wighteone protected the liver, not only against CCl 4 ‐induced hepatotoxicity, but also against D ‐GalN‐induced liver injury. These results demonstrated that wighteone and naringenin are two active hepatoprotective principles from Cudrania cochinchinensis var. gerontogea.