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Assessment of potential for toxicity of Phalaris spp. via alkaloid content determination: P. coerulescens , a case example
Author(s) -
Anderton Neil,
Cockrum Peter A.,
Colegate Steven M.,
Edgar John A.,
Flower Kirsty
Publication year - 1999
Publication title -
phytochemical analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 72
eISSN - 1099-1565
pISSN - 0958-0344
DOI - 10.1002/(sici)1099-1565(199905/06)10:3<113::aid-pca438>3.0.co;2-#
Subject(s) - chemistry , alkaloid , toxicity , environmental chemistry , chromatography , stereochemistry , organic chemistry
Species of Phalaris are useful pasture grasses but can exert neurotoxic and cardiotoxic effects on grazing animals. In view of the unresolved aetiology of the various forms of Phalaris intoxication and the continuing incidents of livestock poisoning on “low‐toxicity” varieties of Phalaris , a strategy is presented for the comprehensive and definitive determination of alkaloid content in Phalaris spp. using thin layer chromatography, high performance liquid chromatography and gas chromatography coupled with mass spectrometry. This integrated approach to alkaloid determination has highlighted the presence of alkaloids previously not associated with Phalaris spp. toxicity. Copyright © 1999 John Wiley & Sons, Ltd.