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Brain metabolic alterations in Cushing's syndrome as monitored by proton magnetic resonance spectroscopy
Author(s) -
Khiat Abdesslem,
Bard Céline,
Lacroix André,
Rousseau Julie,
Boulanger Yvan
Publication year - 1999
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/(sici)1099-1492(199910)12:6<357::aid-nbm584>3.0.co;2-u
Subject(s) - proton magnetic resonance , cushing's disease , choline , metabolite , medicine , endocrinology , cushing syndrome , magnetic resonance imaging , cushing disease , pathology , nuclear magnetic resonance , disease , radiology , physics
Proton magnetic resonance spectroscopy ( 1 H MRS) was used to evaluate changes in cerebral metabolites in 13 patients with Cushing's syndrome (including seven with pituitary corticotroph adenomas and six with primary adrenal disease) as compared to 40 normal subjects. Data were recorded in the frontal, thalamic and temporal areas; quantification of the MRS signals demonstrated a statistically significant decrease of the Cho/Cr ratio in the frontal and thalamic areas but not in the temporal area for patients with Cushing's syndrome. The largest decrease in Cho/Cr was measured in the thalamic area of patients with a Cushing's syndrome secondary to an adrenal disease. No statistically significant changes in the NAA/Cr ratio were measured in any of the areas studied. These results suggest that the quantification of choline levels could be helpful for monitoring the cerebral metabolite alterations in patients with hypercortisolism. Copyright © 1999 John Wiley & Sons, Ltd.