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Magnetic resonance angiography of the rat cerebrovascular system without the use of contrast agents
Author(s) -
Reese Torsten,
Bochelen Damien,
Sauter André,
Beckmann Nicolau,
Rudin Markus
Publication year - 1999
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/(sici)1099-1492(199906)12:4<189::aid-nbm557>3.0.co;2-o
Subject(s) - magnetic resonance angiography , occlusion , magnetic resonance imaging , contrast (vision) , medicine , angiography , inflow , hemodynamics , blood flow , middle cerebral artery , radiology , nuclear medicine , cardiology , ischemia , computer science , artificial intelligence , physics , mechanics
We describe and discuss the application of three‐dimensional (3D) time‐of‐flight (TOF) magnetic resonance angiography (MRA) to visualize non‐invasively the cerebral vasculature of the rat. MR angiograms of healthy spontaneously hypertensive rats were obtained without the use of contrast agents. Total imaging time ranged from 1 to 50 min for a 3D data set. The influences of the data matrix and the inflow delay on the image quality and the total imaging time are assessed and discussed. Varying the inflow delay yielded in addition semiquantitative information on hemodynamics. The method was applied to obtain angiograms in rat models of permanent and temporal middle cerebral artery occlusion. Occlusion and reopening of the vessel could easily be verified byMRA. However, after reperfusion a slight reduction in blood flow was observed. Copyright © 1999 John Wiley & Sons, Ltd.