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Rapid and continuous monitoring of cerebral perfusion by magnetic resonance line scan assessment with arterial spin tagging
Author(s) -
Branch Craig A.,
Hernandez Luis,
Yongbi Martin,
Huang N. C.,
Helpern J. A.
Publication year - 1999
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/(sici)1099-1492(199902)12:1<15::aid-nbm542>3.0.co;2-i
Subject(s) - perfusion , temporal resolution , nuclear magnetic resonance , arterial spin labeling , magnetic resonance imaging , cerebral perfusion pressure , perfusion scanning , continuous monitoring , penumbra , nuclear medicine , biomedical engineering , chemistry , medicine , radiology , physics , ischemia , optics , operations management , economics
A new approach is presented for rapid and continuous monitoring of cerebral perfusion which is based upon line‐scan MR column imaging with arterial spin tagging (AST) of endogenous water. Spin tagging of arterial water protons is accomplished using adiabatic fast passage inversion, followed by acquisition of the perfusion sensitive MR signal from a column placed at the desired level through the brain using line scan localization techniques. A perfusion sensitive line scan is followed by a non‐perfusion sensitive line scan, and perfusion is calculated pixel‐by‐pixel from the intensity difference of the two lines. Continuous perfusion measurements are reported with temporal resolution of 10 s in pixels of volume 0.027 cm 3 or less. Examples of the methodology are given during hypercapnic challenge induced with carbon dioxide, and during an ischemic event induced by reversible middle cerebral artery occlusion. The method is also used to characterize the signal response as a function of arterial inversion time and post inversion acquisition delay. These methods permit rapid and continuous monitoring of cerebral perfusion with high spatial resolution, and can be interleaved with MR measurements of diffusion and T 1 to follow the progression of cerebral events during physiological or pharmacological intervention. Copyright © 1999 John Wiley & Sons, Ltd.