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Biological and clinical MRS at ultra‐high field
Author(s) -
Hetherington H. P.,
Pan J. W.,
Chu W.J.,
Mason G. F.,
Newcomer B. R.
Publication year - 1997
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/(sici)1099-1492(199712)10:8<360::aid-nbm477>3.0.co;2-8
Subject(s) - creatine , glutamine , nuclear magnetic resonance , choline , glutamate receptor , in vivo magnetic resonance spectroscopy , spectral resolution , resolution (logic) , spectroscopy , chemistry , materials science , computer science , physics , magnetic resonance imaging , amino acid , spectral line , biochemistry , medicine , artificial intelligence , receptor , quantum mechanics , astronomy , radiology
The advantages of performing spectroscopic studies at higher field strengths include increased SNR, improved spectral resolution for J ‐coupled resonances, and improvements in the selectivity of spectral editing schemes. By using pulse sequences that minimize the required echo time, refocus J ‐evolution, employ low peak B 1 requiring pulses and take advantage of spectroscopic imaging methods, these advantages can also be utilized in clinical applications of spectroscopy at high field. In addition to the static measurements measurements of N ‐acetyl aspartate (NAA), creatine (CR) and choline (CH) which can be performed at 1.5 T, high resolution measurements of glutamate, glutamine, GABA and the incorporation of 13 C labeled glucose into glutamate are possible with improved spatial and spectral resolution. These methods have been utilized in patients with seizure disorders and multiple sclerosis to identify, characterize and map the metabolic changes associated with these diseases and their treatment. © 1997 John Wiley & Sons, Ltd.