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High spatial resolution MRI and proton MRS of human frontal cortex
Author(s) -
LópezVillegas Dolores,
Kimura Hirohiko,
Tunlayadechat Supoch,
Lenkinski Robert E.
Publication year - 1996
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/(sici)1099-1492(199610)9:7<297::aid-nbm433>3.0.co;2-4
Subject(s) - creatine , choline , nuclear magnetic resonance , voxel , white matter , cortex (anatomy) , human brain , metabolite , chemistry , proton magnetic resonance , high resolution , magnetic resonance imaging , nuclear medicine , physics , medicine , neuroscience , biology , radiology , geology , biochemistry , remote sensing
High‐resolution MR imaging (312 μm in plane resolution) and MR spectroscopy (0.36 cm 3 nominal voxel) have been performed on human frontal cortex using a 3 in surface coil. Localised proton sprectra have been obtained from contiguous 6x6x10 mm voxels using one‐dimensional phase encoding, TR 2000 ms and TE 31 ms. Seven healthy subjects were studied using this approach. The spectra from frontal gray matter showed a reproducible pattern characterized by a choline to creatine and N ‐acetylaspartate to creatine ratio significantly lower than those from cortical white matter. These metabolite ratio differences reflect the lower choline and higher creatine content in gray matter. These prliminary results show the potential of this high spatial‐resolution approach for studying brain cortex. © 1996 John Wiley & Sons, Ltd.