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Use of the Fourier Series Window Protocol with a Zig‐Zag Surface Coil in 31 P NMR Human Skin Spectroscopy. A Theoretical Study
Author(s) -
Bastin Mark E.,
Cowie Alistair G.,
Manners David N.,
Hands Linda J.,
Styles Peter
Publication year - 1996
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/(sici)1099-1492(199608)9:5<201::aid-nbm417>3.0.co;2-4
Subject(s) - electromagnetic coil , signal (programming language) , nuclear magnetic resonance , pulse (music) , materials science , fourier transform , surface (topology) , spectroscopy , skeletal muscle , nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , biomedical engineering , chemistry , optics , computer science , physics , anatomy , geometry , detector , mathematics , biology , engineering , quantum mechanics , chromatography , programming language
The use of a zig‐zag surface coil with a three‐pulse Fourier Series Window (FSW) has been suggested as a means by which in vivo NMR spectroscopic studies of human skin can be performed. Using direct numerical simulations of the magnetic field profile of a 10 limb zig‐zag surface coil, the role of the FSW in reducing NMR signals originating from the deeper skeletal muscle layers is examined theoretically. The extent of muscle signal contamination is determined for different coil inter‐limb spacings and pulse width settings. The optimum inter‐limb spacing for studying living human skin, that which minimizes signal contamination and maximizes skin signal collected, is shown to be between 4 and 6 mm. These calculations demonstrate that the FSW and zig‐zag surface coil offer a protocol for investigating the metabolism of large areas of surface tissue while keeping signal contamination from the deeper skeletal muscle layers down to an acceptable level.