Premium
Optimization of Magnetization Transfer Experiments to Measure First‐Order Rate Constants and Spin‐Lattice Relaxation Times
Author(s) -
Katki Hormuzd,
Weiss George H.,
Kiefer James E.,
Taitelbaum Haim,
Spencer Richard G. S.
Publication year - 1996
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/(sici)1099-1492(199605)9:3<135::aid-nbm404>3.0.co;2-h
Subject(s) - magnetization , magnetization transfer , measure (data warehouse) , relaxation (psychology) , statistical physics , simple (philosophy) , set (abstract data type) , lattice (music) , physics , thermodynamics , condensed matter physics , materials science , computer science , quantum mechanics , magnetic field , data mining , medicine , psychology , social psychology , magnetic resonance imaging , acoustics , radiology , philosophy , epistemology , programming language
A recent analysis of the optimization of magnetization transfer experiments to estimate first‐order rate constants is extended to the design of experiments for measuring these constants and T 1 when both parameters are initially unknown. When the number of measurement times is fixed, an optimal design will consist of a set of measurement times which ensures that the precision of the estimates of the combination of k and T 1 is as small as possible in a worst‐case scenario. Simple expressions are given for the parameters that characterize the optimal design.