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Proton MR T 2 Maps Correlate With The Citrate Concentration in the Prostate
Author(s) -
Liney Gary P.,
Lowry Martin,
Turnbull Lindsay W.,
Manton David J.,
Knowles Adrian J.,
Blackband Stephen J.,
Horsman Anthony
Publication year - 1996
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/(sici)1099-1492(199604)9:2<59::aid-nbm400>3.0.co;2-2
Subject(s) - prostate , hyperplasia , chemistry , resolution (logic) , nuclear magnetic resonance , prostate carcinoma , urology , endocrinology , medicine , physics , cancer , computer science , artificial intelligence
A significant correlation between water T 2 relaxation time and citrate concentration in the normal prostate is demonstrated using spatially localized spectroscopy and water T 2 maps. These data imply that MR images may be used to infer the concentration of citrate at high spatial resolution. Preliminary results in patients demonstrate that this relationship is maintained in benign prostatic hyperplasia (BPH) and prostatic carcinoma. The determination of citrate concentration and water T 2 may aid the differentiation of prostate carcinoma from BPH and normal tissue.