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Ultrafast Perfusion‐Weighted MRI of Functional Brain Activation in Rats During Forepaw Stimulation: Comparison with T * 2 ‐Weighted MRI
Author(s) -
Kerskens Christian M.,
HoehnBerlage Mathias,
Schmitz Bernd,
Busch Elmar,
Bock Christian,
Gyngell Michael L,
Hossmann KonstantinAlexander
Publication year - 1996
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/(sici)1099-1492(199602)9:1<20::aid-nbm381>3.0.co;2-r
Subject(s) - perfusion , perfusion scanning , stimulation , somatosensory system , nuclear magnetic resonance , nuclear medicine , medicine , arterial spin labeling , biomedical engineering , cardiology , physics , psychiatry
A fast version of the arterial spin tagging technique for the detection of cerebral perfusion is presented. Based on adiabatic spin inversion in combination with snapshot FLASH imaging, our technique allows the recording of perfusion changes with a temporal resolution of about 3 s. Differences of cerebral perfusion dependent on the choice of anesthesia were observed in rat brain. Furthermore, with this arterial spin tagging method we demonstrated perfusion increases in the somatosensory cortex of anaesthetized rats during forepaw stimulation. Comparison of the activated areas in the T * 2 ‐weighted BOLD images and the perfusion‐weighted images showed good spatial correspondence, but the sensitivity to the functional activation was more than ten times higher in the perfusion technique.