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Unravelling seemingly complex chemistry of reactions using electrospray ionization mass spectrometry
Author(s) -
Bakhtiar Ray,
Hop Cornelis E. C. A.
Publication year - 1999
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/(sici)1099-1395(199907)12:7<511::aid-poc160>3.0.co;2-s
Subject(s) - chemistry , electrospray ionization , mass spectrometry , small molecule , molecule , ionization , computational chemistry , drug discovery , electrospray , nanotechnology , combinatorial chemistry , chromatography , organic chemistry , biochemistry , ion , materials science
Since its discovery, electrospray ionization mass spectrometry (ESI‐MS) has provided valuable information on structurally specific biomolecular interactions, including DNA–drug, enzyme–inhibitor, DNA–protein and protein–protein interactions. In addition, this technique has emerged as a powerful tool in probing the structural modification of large molecules. However, ESI‐MS has been underutilized in analysis and mechanistic studies involving small molecules. Here, a brief overview is presented to familiarize non‐specialists with ESI‐MS applications in analysis and mechanistic studies of small molecules. For more advanced applications (e.g. biopolymers) or detailed analytical descriptions of the ionization processes and the equipment, readers are referred to a number of excellent reviews and books. Copyright © 1999 John Wiley & Sons, Ltd.