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Hydrogen bonding interactions between Starburst dendrimers and several molecules of biological interest
Author(s) -
Santo Marisa,
Fox Marye Anne
Publication year - 1999
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/(sici)1099-1395(199904)12:4<293::aid-poc88>3.0.co;2-q
Subject(s) - chemistry , dendrimer , hydrogen bond , molecule , nanotechnology , computational chemistry , combinatorial chemistry , organic chemistry , materials science
1 H NMR spectroscopy was used to analyze the interactions between poly(amidoamine) (PAMAM) Starburst dendrimers (SBDs) 1–4 and several biologically important guests (pyridine, quinoline, quinazoline, nicotine and trimethadione). Association constants obtained from changes in the chemical shifts of the amide protons in the host indicate two different interaction sites inside and on the periphery of the dendrimer. Binding at the inner site is inhibited in the ester‐terminated dendrimers. Copyright © 1998 John Wiley & Sons, Ltd.