Premium
Complexation of basic amino acids by water‐soluble calixarene sulphonates as a study of the possiblemechanisms of recognition of calixarene sulphonates by proteins
Author(s) -
DouteauGuével Nathalie,
Coleman Anthony W.,
Morel JeanPierre,
MorelDesrosiers Nicole
Publication year - 1998
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/(sici)1099-1395(1998100)11:10<693::aid-poc18>3.0.co;2-8
Subject(s) - calixarene , chemistry , lysine , arginine , amino acid , stereochemistry , molecule , medicinal chemistry , organic chemistry , biochemistry
The interactions of calixarene sulphonates with the basic amino acids arginine and lysine were studied by 1 H NMR spectroscopy. Strong electrostatic binding occurs for calix[4]arene sulphonate with both lysine and arginine at pH 1 and 5. For the higher calixarenes, only weak interactions at the faces of the flattened macrocycles occur. This binding is in contrast to the inhibition of protein–protein interactions by the calixarenes where the calix[6]arene and calix[8]arene sulphonates show much stronger effects. © 1998 John Wiley & Sons, Ltd.