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Solid phase synthesis of C‐ terminal peptide amides: development of a new aminoethyl‐polystyrene linker on the Multipin™ solid support
Author(s) -
Bui Chinh T.,
Bray Andrew M.,
Nguyen Thao,
Ercole Francis,
Maeji N. Joe
Publication year - 2000
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/(sici)1099-1387(200005)6:5<243::aid-psc251>3.0.co;2-4
Subject(s) - linker , solid phase synthesis , polystyrene , peptide , yield (engineering) , combinatorial chemistry , chemistry , peptide synthesis , phase (matter) , alkylation , organic chemistry , materials science , catalysis , biochemistry , polymer , computer science , metallurgy , operating system
A new aminoethyl‐polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu t protecting groups (30–50% TFA in DCM) and the desired product can be finally cleaved off the solid support in 95% TFA (5% H 2 O). Model peptide amides and other N‐ alkylated peptide amides have been successfully synthesized in good yield and purity. Copyright © 2000 European Peptide Society and John Wiley & Sons, Ltd.