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GABA‐induced changes of the tissue‐specific peptide pool of white rat brain
Author(s) -
Karelin Andrei A.,
Philippova Marina M.,
Karelina Elena V.,
Strizhkov Boris N.,
Nazimov Igor V.,
Ivanov Vadim T.,
Danilova Raisa A.,
Ashmarin Igor P.
Publication year - 2000
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/(sici)1099-1387(200004)6:4<168::aid-psc243>3.0.co;2-s
Subject(s) - edman degradation , peptide , neurotransmitter , chemistry , gamma aminobutyric acid , brain tissue , biochemistry , amino acid , peptide sequence , biology , microbiology and biotechnology , neuroscience , receptor , gene
Internasal administration of γ‐aminobutyric acid (GABA) induced prolonged behaviour changes and the appearance of three new compounds absent in the brain extracts of control rats. Two peptides associated with GABA administration were isolated and sequenced: Thr‐Tyr‐Thr‐Phe, which corresponds to a γ‐immunoglobulin segment, and Val‐Leu, which is present in a great number of proteins, hence its precursor could not be established. The third compound was not amenable to the Edman degradation technique. The data obtained show that the introduction of a neurotransmitter could cause specific changes in the levels of tissue‐specific peptide components. Copyright © 2000 European Peptide Society and John Wiley & Sons, Ltd.