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Acetophenone‐based linker for solid‐phase peptide synthesis
Author(s) -
Bui Chinh T.,
Bray Andrew M.,
Nguyen Thao,
Ercole Francesca,
Rasoul Firas,
Sampson Wayne,
Maeji N. Joe
Publication year - 2000
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/(sici)1099-1387(200002)6:2<49::aid-psc239>3.0.co;2-6
Subject(s) - linker , trifluoroacetic acid , moiety , chemistry , solid phase synthesis , acetophenone , dichloromethane , polystyrene , combinatorial chemistry , peptide synthesis , phase (matter) , peptide , polymer chemistry , organic chemistry , polymer , catalysis , biochemistry , solvent , computer science , operating system
A new and cost‐effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhase™ crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10–20% trifluoroacetic acid (TFA) in dichloromethane (DCM). Solid‐phase syntheses of model decapeptides using this linker are described. Copyright © 2000 European Peptide Society and John Wiley & Sons, Ltd.