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Comparative studies of Nsc and Fmoc as N α ‐ protecting groups for SPPS
Author(s) -
Ramage Robert,
Jiang Lu,
Kim YoungDeug,
Shaw Kevin,
Park JinLi,
Kim HackJoo
Publication year - 1999
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/(sici)1099-1387(199904)5:4<195::aid-psc203>3.0.co;2-g
Subject(s) - chemistry , protecting group , combinatorial chemistry , peptide , amino acid , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , alkyl
2‐(4‐Nitrophenyl)sulfonylethoxycarbonyl (Nsc) is an alternative base‐labile N α ‐protecting group to 9‐fluorenylmethoxycarbonyl (Fmoc) for amino acids. The UV spectrum of the Nsc group exhibits moderate absorption at 380 nm which is excellent for real‐time monitoring of the deprotection process. It also decreases the rearrangement of X‐Asp, which can be a serious problem in SPPS. Copyright © 1999 European Peptide Society and John Wiley & Sons, Ltd.