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Efficient one‐pot synthesis of N‐ethyl amino acids
Author(s) -
Rückle Thomas,
Dubray Benoit,
Hubler Francis,
Mutter Manfred
Publication year - 1999
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/(sici)1099-1387(199901)5:1<56::aid-psc186>3.0.co;2-j
Subject(s) - reductive amination , acetaldehyde , chemistry , imine , amino acid , amination , organic chemistry , peptide , peptide synthesis , combinatorial chemistry , biochemistry , catalysis , ethanol
Mono‐N‐ethylated α‐amino acid esters are obtained in high yields using reductive amination procedures. Formation of imine is achieved by excess of acetaldehyde, followed by removal of acetaldehyde and reduction by NaBH(OAc) 3 . The elaborated one‐pot synthesis allows for the efficient synthesis of side‐chain protected amino acid derivatives. Copyright © 1999 European Peptide Society and John Wiley & Sons, Ltd.