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Construction and synthesis of lactoferricin derivatives with enhanced antibacterial activity
Author(s) -
Rekdal Øystein,
Andersen Jill,
Vorland Lars H.,
Svendsen John S.
Publication year - 1999
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/(sici)1099-1387(199901)5:1<32::aid-psc172>3.0.co;2-9
Subject(s) - lactoferrin , antibacterial peptide , antibacterial activity , peptide , chemistry , sequence (biology) , biochemistry , bovine milk , microbiology and biotechnology , combinatorial chemistry , biology , bacteria , genetics
A series of peptides derived from sequences from human, bovine, murine and caprine lactoferrin has been prepared and investigated for antibacterial effect. Among the four species investigated peptides based on the bovine sequence displayed significant activity. The bovine sequence, bovine lactoferricin, showed a MIC value of 30 μg/mL on E. coli and S. aureus , whereas the three other lactoferricins possessed MIC values above 200 μg/mL. Based on these findings, novel peptides with enhanced antibacterial activities, were prepared with sequences designed by molecular modelling and structure‐activity studies. Copyright © 1999 European Peptide Society and John Wiley & Sons, Ltd.