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An efficient and convenient procedure for the synthesis of n α ‐Fmoc‐ O ‐monobenzyl phosphonotyrosine
Author(s) -
Handa B.K.,
Hobbs C.J.
Publication year - 1998
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/(sici)1099-1387(199804)4:2<138::aid-psc150>3.0.co;2-w
Subject(s) - combinatorial chemistry , chemistry , yield (engineering) , sodium iodide , derivative (finance) , product (mathematics) , stereochemistry , organic chemistry , mathematics , materials science , geometry , economics , financial economics , metallurgy
An efficient procedure is described for the synthesis of N α ‐Fmoc‐ O ‐monobenzyl phosphonotyrosine from the corresponding dibenzyl derivative by monodebenzylation in the presence of sodium iodide. A simple work up procedure removes the by‐products and the monobenzylated phosphono product is obtained in high yield. © 1998 European Peptide Society and John Wiley & Sons, Ltd.