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Molecular recognition events involved in the activation of the growth hormone receptor by growth hormone
Author(s) -
Behncken Stuart N.,
Waters Michael J.
Publication year - 1999
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/(sici)1099-1352(199911/12)12:6<355::aid-jmr477>3.0.co;2-k
Subject(s) - growth hormone receptor , receptor , molecular recognition , hormone receptor , biochemistry , growth hormone releasing hormone receptor , mutagenesis , hormone , chemistry , biology , microbiology and biotechnology , growth hormone , mutation , gene , genetics , molecule , cancer , organic chemistry , breast cancer
Binding of growth hormone (GH) to its receptor (GHR) is a well‐studied example of molecular recognition between a cytokine and its receptor. Extensive mutagenesis studies and several crystal structures have defined the key interactive amino acid residues that are involved in binding and subsequent receptor dimerization. This review encompasses each of the three molecular recognition events involved in GHR activation, namely binding of GH to its two receptors and the interactions that occur between these receptors. Particular attention is given to species and ligand specificity of hormone binding and to the molecular recognition events involved in receptor activation, including the possibility that a conformational change in the receptor is required. Copyright © 1999 John Wiley & Sons, Ltd.