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Theophylline molecularly imprinted polymer dissociation kinetics: a novel sustained release drug dosage mechanism
Author(s) -
Norell Mikael C.,
Andersson Håkan S.,
Nicholls Ian A.
Publication year - 1998
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/(sici)1099-1352(199812)11:1/6<98::aid-jmr399>3.0.co;2-y
Subject(s) - molecularly imprinted polymer , chemistry , kinetics , polymer , theophylline , monomer , molecular imprinting , polymerization , selectivity , combinatorial chemistry , dissociation (chemistry) , polymer chemistry , organic chemistry , catalysis , pharmacology , medicine , physics , quantum mechanics
The template release kinetics of theophylline molecularly imprinted polymers has been examined with a view to determining their potential as a controlled release drug dosage form. The basis for the ligand selectivity of these polymers has been shown through the demonstration of pre‐polymerization template– monomer complexation and HPLC studies of the product polymer ligand selectivities. The release kinetics shows a dependence upon template loading and pH. Small differences in release characteristics between imprinted and non‐imprinted (reference) polymers have been observed. Copyright © 1998 John Wiley & Sons, Ltd.