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Spectroscopic studies of the molecular imprinting self‐assembly process
Author(s) -
Svenson Johan,
Andersson Håkan S.,
Piletsky Sergey A.,
Nicholls Ian A.
Publication year - 1998
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/(sici)1099-1352(199812)11:1/6<83::aid-jmr395>3.0.co;2-p
Subject(s) - trifluoroacetic acid , methacrylic acid , monomer , molecular imprinting , polymerization , chemistry , dipeptide , polymer chemistry , self assembly , titration , organic chemistry , polymer , amino acid , selectivity , biochemistry , catalysis
A method for the rapid estimation of the extent of complex formation in molecular imprinting pre‐polymerization mixtures is described. By the use of a UV spectroscopy titration procedure, apparent binding constants for such self‐assembly processes have been obtained. This method was used for comparison of the interactions between a dipeptide template ( N ‐acetyl‐ L ‐phenylalaninyl‐ L ‐tryptophanyl methyl ester) and the functional monomer methacrylic acid, and the monomer analogues acetic acid and trifluoroacetic acid. The importance of template–monomer association during the molecular imprinting pre‐polymerization phase is discussed with respect to the systems studied. Copyright © 1998 John Wiley & Sons, Ltd.