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Synthesis of 16α‐[ 18 F]fluoroestradiol‐3,17β‐disulphamate
Author(s) -
Römer J.,
Füchtner F.,
Steinbach J.
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(200004)43:5<425::aid-jlcr327>3.0.co;2-u
Subject(s) - chemistry , yield (engineering) , potassium carbonate , radiochemistry , specific activity , acetonitrile , chloride , nuclear chemistry , potassium , organic chemistry , thermodynamics , enzyme , physics
The synthesis of 16α‐[ 18 F]Fluoroestradiol‐3,17β‐disulphamate ([ 18 F]FESDS) is described. 16α‐[ 18 F]Fluoroestradiol ([ 18 F]FES) is converted using excess sulphamoyl chloride in absolute acetonitrile in the presence of Kryptofix 2.2.2 and potassium carbonate using an automatically operating module. The required time for the synthesis related to end of bombardment is 3 h, the maximum yield is 6%, and the maximum decay‐corrected yield is 20%. The radiochemical purity of [ 18 F]FESDS is >99%. The specific radioactivity of [ 18 F]FESDS is found to be between 150 and 200 GBq/μmol. Copyright © 2000 John Wiley & Sons, Ltd.