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Lysine conjugates for the labelling of peptides with technetium‐99m and rhenium
Author(s) -
Hunter Duncan H.,
Luyt Leonard G.
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(20000330)43:4<403::aid-jlcr330>3.0.co;2-m
Subject(s) - chemistry , peptide , lysine , rhenium , conjugate , chelation , bifunctional , labelling , peptide synthesis , yield (engineering) , combinatorial chemistry , technetium , conjugated system , radiochemistry , stereochemistry , amino acid , organic chemistry , nuclear chemistry , biochemistry , polymer , catalysis , mathematical analysis , materials science , mathematics , metallurgy
A novel method of preparing 99m Tc labelled peptides, through the incorporation of a lysine analogue containing a metal chelation centre, is proposed. α‐CBZ‐Lysine has been conjugated to an N 2 S 2 bifunctional chelator yielding 1 , which has been chelated with both rhenium and technetium‐99m and can yield a single isomer product. A Fmoc protected lysine analogue 2 , has been prepared, and is ready for incorporation into a peptide by standard peptide synthetic methods, with the potential of the forming a single isomer 99m Tc labelled peptide. Copyright © 2000 John Wiley & Sons, Ltd.