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Synthesis of 8‐[ 10 B]‐dihydroxyboryl‐harmine, a potential agent for boron neutron capture therapy
Author(s) -
Sintas Jose A.,
Macareno Norberto J.,
Vitale Arturo A.
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(200001)43:1<97::aid-jlcr296>3.0.co;2-d
Subject(s) - harmine , chemistry , neutron capture , boron , radiochemistry , nuclear chemistry , combinatorial chemistry , organic chemistry , pharmacology , medicine
The preparation and spectral properties (MS, IR and NMR) of 8‐[ 10 B]‐dihydroxyborylharmine (III) are described. A general synthetic method was developed for an efficient production of boronated harmine; a potential agent for boron neutron capture therapy (BNCT) in brain. Copyright © 2000 John Wiley & Sons, Ltd.