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[ 11 C]Diazepam synthesis: N‐[ 11 C]methylation of desmethyldiazepam is facilitated by utilization of a preformed sodium salt/benzo‐15‐crown‐5 complex
Author(s) -
Sassaman Mark B.,
Panico Mariarosaria,
Schmall Bernard,
Eckelman William C.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(19991230)42:13<1229::aid-jlcr278>3.0.co;2-s
Subject(s) - chemistry , salt (chemistry) , methylation , sodium , solvent , nucleophile , alkylation , crown (dentistry) , sodium salt , diazepam , organic chemistry , nuclear chemistry , medicinal chemistry , inorganic chemistry , pharmacology , biochemistry , catalysis , medicine , dentistry , gene
The use of a preformed desmethyldiazepam sodium salt/benzo‐15‐crown‐5 complex in aprotic media allows for rapid and clean [ 11 C]methylation without contamination and loss of activity due to alkylation of solvent residues and other dissolved basic‐nucleophilic material. Copyright © 1999 John Wiley & Sons, Ltd.