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Synthesis of an iodine‐labelled analogue of practolol: ( S )‐3‐[4‐(4‐iodobut‐3‐encarboxamido)phenoxy]‐1‐isopropylaminopropan‐2‐ol (AMI‐9S)
Author(s) -
Apparu Marcel,
Ben Tiba Younes,
Léo PierreMarc,
Mathieu Jean Paul,
Mauclaire Laurent
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199912)42:12<1195::aid-jlcr275>3.0.co;2-r
Subject(s) - chemistry , enantiomer , iodine , chloramine t , stannane , iodide , halogenation , methyl iodide , medicinal chemistry , stereochemistry , organic chemistry
AMI‐9S was synthesized in the S configuration with an enantiomeric purity of over 97% and labelled with iodine‐123 with a specific activity of 300 Ci/mmol. Enantiomeric purity was determined by 19 F NMR spectroscopy following derivatisation using ( R )‐2‐fluorophenylacetylchloride. Radio‐iodination was carried out from a vinylic stannane in the presence of iodide and chloramine T. Copyright © 1999 John Wiley & Sons, Ltd.