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Synthesis of [carbonyl‐ 14 C]‐4‐benzoylbenzoic acid, a photolabelling reagent
Author(s) -
Gomis JM.,
Santolini J.,
André F.,
Noel JP.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199912)42:12<1175::aid-jlcr272>3.0.co;2-5
Subject(s) - chemistry , benzoic acid , yield (engineering) , reagent , specific activity , organic chemistry , enzyme , materials science , metallurgy
[carbonyl‐ 14 C]‐4‐Benzoylbenzoic acid, a photolabelling reagent, was synthesised with high specific activity in 57% radioactive yield from [carboxyl‐ 14 C]‐benzoic acid. Radioactive synthesis allowed elucidation of the mechanism of a previous unlabelled synthesis using benzoic acid, methyl ester. An improvement in the experimental conditions led to a new synthesis of radioactive benzoylbenzoic derivatives with good yield. Copyright © 1999 John Wiley & Sons, Ltd.